| Game | Date | Kickoff | Opponent | Final |
| Pre | Fri, Aug. 13 | 1:00 PM |  |
49ers 7 Raiders 34 |
| Pre | Sat, Aug. 19 | 5:30 PM |  |
49ers 21 Broncos 20 |
| Pre | Fri, Aug. 25 | 7:00 PM |  |
49ers 12 Chargers 23 |
| 1 | Sun, Sep. 10 | 10:00 AM |  |
49ers 30 Steelers 7 |
| 2 | Sun, Sep. 17 | 1:05 PM |  |
49ers 30 Rams 23 |
| 3 | Thurs, Sep. 21 | 5:15 PM |  |
49ers 30 Giants 12 |
| 4 | Sun, Oct. 1 | 1:25 PM |  |
49ers 35 Cardinals 16 |
| 5 | Sun, Oct. 8 | 5:20 PM |  |
49ers 42 Dallas 10 |
| 6 | Sun, Oct. 15 | 10:00 AM |  |
49ers 17 Browns 19 |
| 7 | Mon, Oct. 23 | 5:15 PM |  |
49ers 17 Vikings 22 |
| 8 | Sun, Oct. 29 | 1:25 PM |  |
49ers 17 Bengals 31 |
| 9 | Sun, Nov. 5 | Bye Week | |||
| 10 | Sun, Nov. 12 | 10:00 AM |  |
49ers 34 Jaguars 3 |
| 11 | Mon, Nov. 19 | 1:05 PM |  |
49ers 27 Buccaneers 14 |
| 12 | Thurs, Nov. 23 | 5:20 PM |  |
49ers 31 Seahawks 13 |
| 13 | Sun, Dec. 3 | 1:25 PM |  |
49ers 42 Eagles 19 |
| 14 | Sun, Dec. 10 | 1:05 PM | |
49ers vs. Seahawks |
| 15 | Thurs. Dec. 17 | 1:05 PM | |
49ers at Cardinals |
| 16 | Mon, Dec. 25 | 5:15 PM |  |
49ers vs. Ravens |
| 17 | Sun, Dec. 31 | 10:00 AM |  |
49ers at Commanders |
| 18 | Sat/Sun, Jan. 6/7 | TBD | |
49ers vs. Rams |