| Game | Date | Kickoff | Opponent | Final |
|---|---|---|---|---|
| Pre | Fri, Aug. 13 | 1:00 PM |  | 49ers 7 Raiders 34 |
| Pre | Sat, Aug. 19 | 5:30 PM |  | 49ers 21 Broncos 20 |
| Pre | Fri, Aug. 25 | 7:00 PM |  | 49ers 12 Chargers 23 |
| 1 | Sun, Sep. 10 | 10:00 AM |  | 49ers 30 Steelers 7 |
| 2 | Sun, Sep. 17 | 1:05 PM |  | 49ers 30 Rams 23 |
| 3 | Thurs, Sep. 21 | 5:15 PM |  | 49ers 30 Giants 12 |
| 4 | Sun, Oct. 1 | 1:25 PM |  | 49ers 35 Cardinals 16 |
| 5 | Sun, Oct. 8 | 5:20 PM |  | 49ers 42 Dallas 10 |
| 6 | Sun, Oct. 15 | 10:00 AM |  | 49ers 17 Browns 19 |
| 7 | Mon, Oct. 23 | 5:15 PM |  | 49ers 17 Vikings 22 |
| 8 | Sun, Oct. 29 | 1:25 PM |  | 49ers 17 Bengals 31 |
| 9 | Sun, Nov. 5 | Bye Week | |||
| 10 | Sun, Nov. 12 | 10:00 AM |  | 49ers 34 Jaguars 3 |
| 11 | Mon, Nov. 19 | 1:05 PM |  | 49ers 27 Buccaneers 14 |
| 12 | Thurs, Nov. 23 | 5:20 PM |  | 49ers 31 Seahawks 13 |
| 13 | Sun, Dec. 3 | 1:25 PM |  | 49ers 42 Eagles 19 |
| 14 | Sun, Dec. 10 | 1:05 PM | | 49ers 28 Seahawks 16 |
| 15 | Thurs. Dec. 17 | 1:05 PM | | 49ers 45 Cardinals 29 |
| 16 | Mon, Dec. 25 | 5:15 PM |  | 49ers 19 Ravens 33 |
| 17 | Sun, Dec. 31 | 10:00 AM |  | 49ers 27 Commanders 10 |
| 18 | Sun, Jan. 7 | 1:25 PM | | 49ers 20 Rams 21 |
| 19 | Sat, Jan. 20 | 1:25 PM |  | 49ers 24 Green Day 21 |
| 20 | Sun, Jan. 28 | 3:30 PM |  | 49ers 34 Detroit 31 |
| 21 | Sun, Feb. 11 | 3:30 PM |  | Las Vegas |
